UVA Health System frequently opens new clinical trials, offering your patients the latest investigational treatments.
For a complete list of active cancer trials and study coordinator contact information, visit our newly launched Find a Clinical Trial website. If you have patients who may be eligible to participate in a cancer clinical trial, please email cancerclinicaltrials@virginia.edu.
Breast Oncology (IRB-HSR #21310)
A Phase III Randomized, Open-Label, Active-Controlled, Multicenter Trial of Elacestrant Monotherapy Vs. Standard of Care for the Treatment of Patients with ER+/HER2- Advanced Breast Cancer Following CDK4/6 Inhibitor Therapy (NCT03778931)
Primary Investigator: Patrick Dillon
Clinical Research Coordinator: Jake Boyd
Adenocarcinoma of the Pancreas (IRB-HSR #20984)
A Randomized, Controlled, Open-Label, Adaptive Phase III Trial to Evaluate Safety and Efficacy of EndoTAG-1 Plus Gemcitabine versus Gemcitabine Alone in Patients with Measurable Locally Advanced and/or Metastatic Adenocarcinoma of the Pancreas Failed on FOLFIRINOX Treatment (NCT03126435)
Primary Investigator: Paul Kunk
Clinical Research Coordinator: Linsey Jackson
Advanced Gastrointestinal Stromal Tumors (IRB-HSR #21118)
A Phase 3, Interventional, Randomized, Multicenter, Open-Label Study of DCC-2618 Vs. Sunitinib in Patients with Advanced Gastrointestinal Stromal Tumors After Treatment with Imatinib (NCT03673501)
Primary Investigator: Matthew Reilley
Clinical Research Coordinator: Sallie Mannen
Endometrial Cancer (IRB-HSR #21063)
Randomized Phase III Trial of Two Standard Dose Fractinonation Regimens for Adjuvant Vaginal Brachytherapy in Early Stage Endometrial (NCT03785288)
Primary Investigator: Timothy Showalter, MD
Clinical Research Coordinator email: cancerclinicaltrials@virginia.edu
Breast Oncology (IRB-HSR #20518)
Single-Arm, Open Label Phase 1b/2 Study of SGN-LIV1A in Combination with Pembrolizumab for First-Line Treatment of Patients with Unresectable, Locally-Advanced or Metastatic Triple-Negative Breast Cancer (NCT03310957)
Primary Investigator: Patrick Dillon
Clinical Research Coordinator: Jake Boyd
Breast Oncology (IRB-HSR #20295)
Randomized and Blinded Clinical Evaluation of DermACELL Without Basement Membrane in Breast Reconstruction
Primary Investigator: Patrick Cottler
Clinical Research Coordinator: Dena Synyder
Genitourinary Oncology (IRB-HSR #20610)
ATLAS: A Phase 2, Open-label Study of Rucaparib in Patients with Locally Advanced or Metastatic Urothelial Carcinoma (NCT03397394)
Primary Investigator: Robert Dreicer
Clinical Research Coordinator: Julio Torres
Hematologic Malignancies (IRB-HSR #20613)
A Multicenter Phase 2 Study to Evaluate Subcutaneous Daratumumab in Combination with Standard Multiple Myeloma Treatment Regimens
Primary Investigator: Laahn Foster
Clinical Research Coordinators: Michal Ande
Hematologic Malignancies (IRB-HSR #20729)
A Phase 3, Randomized, Open-Label Study Evaluating the Efficacy of Axicabtagene Ciloleucel versus Standard of Care Therapy in Subjects with Relapsed/Refractory Diffuse Large B Cell Lymphoma
Primary Investigator: Craig Portell
Clinical Research Coordinator: Amelia Hodson, Kristen L. Johnson
Thoracic Oncology (IRB-HSR #20704)
A Randomized Phase II Trial of Docetaxel plus Nivolumab or Docetaxel alone in patients with advanced squamous or non-squamous NSCLC and previous clinical benefit on treatment with a PD-1 or PD-L1 inhibitor (NCT03041181)
Primary Investigator: Richard Hall
Clinical Research Coordinator: Gracie Tubbs Hockenberry
Idiopathic Parkinson’s Disease (IRB-HSR #180001)
A Pivotal Clinical Trial of the Management of the Medically-Refractory Dyskinesia Symptoms or Motor Fluctuations of Advanced Idiopathic Parkinson’s Disease With Unilateral Lesioning of the Globus Pallidum Using the ExAblate Neuro System (NCT03319485)
Primary Investigator: W. Jeffrey Elias
Clinical Research Coordinator: Matthew Patterson
Idiopathic Parkinson’s Disease (IRB-HSR #17552)
A Randomized Feasibility Clinical Trial of the Management of the Medically-Refractory Motor Symptoms of Advanced Idiopathic Parkinson’s Disease With Unilateral Lesioning of the Subthalamic Nucleus Using the ExAblate Transcranial System
Primary Investigator: W. Jeffrey Elias
Clinical Research Coordinator: Matthew Patterson
Chronic Trigeminal Neuropathic Pain (IRB-HSR #170004)
A Feasibility Study of Focused Ultrasound to Perform Bilateral Medial Thalamotomy for the Treatment of Chronic Trigeminal Neuropathic Pain (NCT03309813)
Primary Investigator: W. Jeffrey Elias
Clinical Research Coordinator: Matthew Patterson
