Clinical Trials

UVA Health System frequently opens new clinical trials, offering your patients the latest investigational treatments.

For a complete list of active cancer trials and study coordinator contact information, visit our newly launched Find a Clinical Trial website. If you have patients who may be eligible to participate in a cancer clinical trial, please email cancerclinicaltrials@virginia.edu.

 

 

 

New Trials Available at UVA

Breast Oncology (IRB-HSR #21310)

A Phase III Randomized, Open-Label, Active-Controlled, Multicenter Trial of Elacestrant Monotherapy Vs. Standard of Care for the Treatment of Patients with ER+/HER2- Advanced Breast Cancer Following CDK4/6 Inhibitor Therapy (NCT03778931)

Primary Investigator: Patrick Dillon
Clinical Research Coordinator: Jake Boyd

Adenocarcinoma of the Pancreas (IRB-HSR #20984)

A Randomized, Controlled, Open-Label, Adaptive Phase III Trial to Evaluate Safety and Efficacy of EndoTAG-1 Plus Gemcitabine versus Gemcitabine Alone in Patients with Measurable Locally Advanced and/or Metastatic Adenocarcinoma of the Pancreas Failed on FOLFIRINOX Treatment (NCT03126435)

Primary Investigator: Paul Kunk
Clinical Research Coordinator: Linsey Jackson

Advanced Gastrointestinal Stromal Tumors (IRB-HSR #21118)

A Phase 3, Interventional, Randomized, Multicenter, Open-Label Study of DCC-2618 Vs. Sunitinib in Patients with Advanced Gastrointestinal Stromal Tumors After Treatment with Imatinib (NCT03673501)

Primary Investigator: Matthew Reilley
Clinical Research Coordinator: Sallie Mannen

Breast Oncology (IRB-HSR #20518)

Single-Arm, Open Label Phase 1b/2 Study of SGN-LIV1A in Combination with Pembrolizumab for First-Line Treatment of Patients with Unresectable, Locally-Advanced or Metastatic Triple-Negative Breast Cancer (NCT03310957)

Primary Investigator: Patrick Dillon
Clinical Research Coordinator: Jake Boyd

Breast Oncology (IRB-HSR #20295)

Randomized and Blinded Clinical Evaluation of DermACELL Without Basement Membrane in Breast Reconstruction

Primary Investigator: Patrick Cottler
Clinical Research Coordinator: Dena Synyder

 

Genitourinary Oncology (IRB-HSR #20610)

ATLAS: A Phase 2, Open-label Study of Rucaparib in Patients with Locally Advanced or Metastatic Urothelial Carcinoma (NCT03397394)

Primary Investigator: Robert Dreicer
Clinical Research Coordinator: Julio Torres

 

Hematologic Malignancies (IRB-HSR #20613)

A Multicenter Phase 2 Study to Evaluate Subcutaneous Daratumumab in Combination with Standard Multiple Myeloma Treatment Regimens

Primary Investigator: Laahn Foster
Clinical Research Coordinators: Michal Ande

Hematologic Malignancies (IRB-HSR #20729)

A Phase 3, Randomized, Open-Label Study Evaluating the Efficacy of Axicabtagene Ciloleucel versus Standard of Care Therapy in Subjects with Relapsed/Refractory Diffuse Large B Cell Lymphoma

Primary Investigator: Craig Portell
Clinical Research Coordinator: Amelia Hodson, Kristen L. Johnson

Thoracic Oncology (IRB-HSR #20704)

A Randomized Phase II Trial of Docetaxel plus Nivolumab or Docetaxel alone in patients with advanced squamous or non-squamous NSCLC and previous clinical benefit on treatment with a PD-1 or PD-L1 inhibitor (NCT03041181)

Primary Investigator: Richard Hall
Clinical Research Coordinator: Gracie Tubbs Hockenberry

Idiopathic Parkinson’s Disease (IRB-HSR #180001)

A Pivotal Clinical Trial of the Management of the Medically-Refractory Dyskinesia Symptoms or Motor Fluctuations of Advanced Idiopathic Parkinson’s Disease With Unilateral Lesioning of the Globus Pallidum Using the ExAblate Neuro System (NCT03319485)

Primary Investigator: W. Jeffrey Elias
Clinical Research Coordinator: Matthew Patterson

Idiopathic Parkinson’s Disease (IRB-HSR #17552)

A Randomized Feasibility Clinical Trial of the Management of the Medically-Refractory Motor Symptoms of Advanced Idiopathic Parkinson’s Disease With Unilateral Lesioning of the Subthalamic Nucleus Using the ExAblate Transcranial System

Primary Investigator: W. Jeffrey Elias
Clinical Research Coordinator: Matthew Patterson

Chronic Trigeminal Neuropathic Pain (IRB-HSR #170004)

A Feasibility Study of Focused Ultrasound to Perform Bilateral Medial Thalamotomy for the Treatment of Chronic Trigeminal Neuropathic Pain (NCT03309813)

Primary Investigator: W. Jeffrey Elias
Clinical Research Coordinator: Matthew Patterson