UVA Recognized for Superior Care of Patients with Cerebral Cavernous Malformations

The Angioma Alliance recently designated UVA Health System as a Clinical Center for providing high-quality interdisciplinary care for patients with cerebral cavernous malformations (CCM).

Also known as cavernous angiomas, CCMs are clusters of abnormally dilated blood vessels that create raspberry-like lesions in the brain or on the spinal cord. CCMs may be asymptomatic, but have a high propensity for bleeding, which can cause seizures. According to the Angioma Alliance, additional risks include neurological deficits such as weakness in the arms or legs as well as problems with vision, balance, memory and attention.

UVA participated in a lengthy, six-month application process to become the first and only CCM Clinical Center in Virginia and currently the only center in the mid-Atlantic and Southeast. This designation will help raise awareness among patients in the region about CCM treatment and clinical studies available at UVA. And it will put UVA on track to achieve Center of Excellence status, the highest level of recognition awarded by the Angioma Alliance.

“This new center designation will help with the medical and surgical management of patients with this challenging disease process and will help spur studies to better understand cavernous malformations and lead to the development of new therapies for patients,” says UVA neurosurgeon Yashar Kalani, MD. “Our efforts are also centered on helping patients and families deal with this disease as a chronic disease and to provide the support needed to patients and families.”

UVA will be the featured center at the Angioma Alliance National Patient Conference being held in Washington, D.C. on Friday, Nov. 9, to Saturday, Nov. 10. The presentations will be live-streamed on the Angioma Alliance YouTube channel.


Members of the UVA CCM Clinical Center team include:

Yashar Kalani, MD — Neurosurgery

Min Park, MD — Neurosurgery

Brad Worrall, MD — Neurology

Andrew Southerland, MD — Neurology

Zuseen Rannigan, RN, MSN, FNP — Neurosurgery, University Physicians Group (UPG)

Barrett Zlotoff, MD — Dermatology

Chelsea Chambers — Genetic Counselor


To refer a patient to UVA Neurosciences and Behavioral Health Center, call UVA Physician Direct at 800.552.3723.